Chromatography

PrimoScience Labs (PSL) offers comprehensive chromatography services, including HPLC, UHPLC, and GC analysis, to support research, development, and manufacturing needs across various industries, such as pharmaceuticals, environmental, food and beverages, petrochemicals, chemicals, cosmetics, and more. PSL provides method development, qualification, validation, along with routine testing. The advanced techniques offered by PSL ensure precise, reliable results for both small molecules and biologics
Reversed-Phase High Pressure Liquid Chromatography (RP-HPLC)
RP-HPLC separates analytes based on hydrophobicity and is suitable to determine:
  • Product purity
  • Impurities
  • Active ingredient(s) quantification
  • Residuals
  • Product stability
High Pressure Size Exclusion Chromatography (HP-SEC)
HP-SEC separates analytes based on size and is used for:
  • Analysis of protein aggregation
  • Impurities
  • Conjugation states for antibody-drug conjugates (ADCs)
  • Product stability
Ion-Exchange Chromatography (IEX)
IEX separates molecules based on charge and can be used to assess:
  • Product purity
  • Impurities
  • Charge heterogeneity
  • Product stability
Hydrophobic Interaction Chromatography (HIC)
HIC is used to separate proteins based on hydrophobic properties and is employed to determine:
  • Product purity
  • Impurities
  • Product stability
Gas Chromatography (GC)
GC is a method used for separating and analyzing compounds that can be volatilized without decomposition. This technique can be used for detection and quantification of:
  • Various compounds
  • Contaminants
  • Residual organics in drugs
  • Pesticides
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